Drug-Repurposing Hub Reference Ingest Guide¶
Source Information¶
InfoRes ID: infores:drug-repurposing-hub
Description: The Drug Repurposing Hub is a curated and annotated collection of FDA-approved drugs, clinical trial drugs, and selected pre-clinical tool compounds. Because the compounds are annotated and well characterized, the collection is a novel tool to explore known biological targets and pathways, and a powerful way to discover new biological insights, better understand disease mechanisms, and discover new activities of existing molecules.
Citations: - {'Corsello SM, Bittker JA, Liu Z, Gould J, McCarren P, Hirschman JE, Johnston SE, Vrcic A, Wong B, Khan M, Asiedu J, Narayan R, Mader CC, Subramanian A, Golub TR. The Drug Repurposing Hub': 'a next-generation drug library and information resource. Nature Medicine. 23, 405–408 (2017).'}
Data Access Locations: - https://repo-hub.broadinstitute.org/repurposing#download-data
Data Provision Mechanisms: file_download
Data Formats: tsv
Data Versioning and Releases: irregular, Latest version: 8/19/2025, Archived versions: 3/24/2020 | 9/7/2018 | 5/16/2018 | 3/27/2017
Ingest Information¶
Ingest Categories: primary_knowledge_provider
Utility: powerful way to discover new biological insights, better understand disease mechanisms, and discover new activities of existing molecules.
Scope: FDA-approved drugs, clinical trial drugs, and selected pre-clinical tool compounds
Relevant Files¶
| File Name | Location | Description |
|---|---|---|
| repo-drug-annotation-20200324.txt | https://repo-hub.broadinstitute.org/public/data/repo-drug-annotation-20200324.txt |
Included Content¶
| File Name | Included Records | Fields Used |
|---|---|---|
| repo-drug-annotation-20200324.txt | all rows | pert_iname, clinical_phase, moa, target, disease_area, indication |
Target Information¶
Target InfoRes ID: infores:translator-drug-repurposing-hub
Edge Types¶
| Subject Categories | Predicate | Object Categories | Knowledge Level | Agent Type | UI Explanation |
|---|---|---|---|---|---|
| biolink:SmallMolecule, biolink:MolecularMixture, biolink:ChemicalEntity | biolink:Gene | knowledge_assertion | manual_agent | mechanism of mechanism and target information | |
| biolink:SmallMolecule, biolink:MolecularMixture, biolink:ChemicalEntity | biolink:DiseaseOrPhenotypicFeature | knowledge_assertion | manual_agent | drug indication |
Node Types¶
| Node Category | Source Identifier Types | Additional Notes |
|---|---|---|
| ChemicalEntity | PubChem | |
| DiseaseOrPhenotypicFeature | MONDO | |
| Gene | HGNC | |
| MolecularMixture | PubChem | |
| SmallMolecule | PubChem |
Future Modeling Considerations¶
qualifiers: map mechanism description text to qualifiers (e.g. 'serine protease inhibitor' => 'causal_mechanism_qualifier: inhibition'
Provenance Information¶
Contributors: - Vlado Dancik - code author, domain expertise - Kevin Schaper - code support - Evan Morris - code support - Sierra Moxon - data modeling, code support - Matthew Brush - data modeling, domain expertise