Multiomics Drug Approvals Knowledge Provider (DAKP) Reference Ingest Guide¶
Source Information¶
InfoRes ID: infores:multiomics-drugapprovals
Description: The Drug Approvals KP provides information on FDA-approved drugs and their approved indications, derived from DailyMed and FAERS data. Information includes drug-disease treatment relationships with FDA approval status, approval numbers, and supporting evidence from adverse event reports.
Citations: - Generating Biomedical Knowledge Graphs from Knowledge Bases, Registries, and Multiomic Data (preprint): (https://pmc.ncbi.nlm.nih.gov/articles/PMC11601480/
Data Access Locations: - Direct download links for the latest version are given in the manifest file: https://github.com/multiomicsKP/drug_approvals_kp/blob/main/manifest.json
Data Provision Mechanisms: file_download
Data Formats: kgx
Data Versioning and Releases: New versions are released periodically
Ingest Information¶
Ingest Categories: translator_knowledge_creator
Utility: DAKP provides curated drug-disease treatment relationships with FDA approval status and supporting evidence. This knowledge is essential for understanding approved therapeutic uses and clinical evidence. DAKP also provides information on drug use in the absence of FDA approval, and information on contraindications.
Scope: FDA-approved drugs and their treatment relationships with diseases, including approval status, FDA approval numbers, and case counts from adverse event reporting; information on drug use in the absence of FDA approval, with case counts from adverse event reporting; and information on contraindications.
Relevant Files¶
| File Name | Location | Description |
|---|---|---|
| DAKP processed data | https://db.systemsbiology.net/gestalt/KG/ | Drug approval data processed from DailyMed and FAERS |
Included Content¶
| File Name | Included Records | Fields Used |
|---|---|---|
| DAKP processed data | Drug-disease treatment relationships with FDA approval information | drug identifiers, disease identifiers, FDA approval numbers, approval status, case counts, evidence IDs |
Target Information¶
Target InfoRes ID: infores:translator-dakp-kgx
Edge Types¶
| Subject Categories | Predicate | Object Categories | Knowledge Level | Agent Type | UI Explanation |
|---|---|---|---|---|---|
| biolink:ChemicalEntity, biolink:SmallMolecule, biolink:MolecularMixture, biolink:ComplexMolecularMixture, biolink:Drug | biolink:Disease, biolink:PhenotypicFeature, biolink:DiseaseOrPhenotypicFeature | knowledge_assertion | text_mining_agent | The 'treats' predicate indicates an FDA-approved therapeutic relationship between a drug and a disease, with supporting regulatory approval information. | |
| biolink:ChemicalEntity, biolink:SmallMolecule, biolink:MolecularMixture, biolink:ComplexMolecularMixture, biolink:Drug | biolink:Disease, biolink:PhenotypicFeature, biolink:DiseaseOrPhenotypicFeature | knowledge_assertion | text_mining_agent | The 'applied_to_treat' predicate indicates an therapeutic relationship between a drug and a disease, without FDA approval, based on usage reports in FAERS. | |
| biolink:ChemicalEntity, biolink:SmallMolecule, biolink:MolecularMixture, biolink:ComplexMolecularMixture, biolink:Drug | biolink:Disease, biolink:PhenotypicFeature, biolink:DiseaseOrPhenotypicFeature | knowledge_assertion | text_mining_agent | The 'contraindicated_in' predicate indicates a contraindication relationship between a drug and a disease or condition, based on warnings present in FDA approval documents. |
Node Types¶
| Node Category | Source Identifier Types | Additional Notes |
|---|---|---|
| biolink:ChemicalEntity | CHEBI, UNII | |
| biolink:SmallMolecule | CHEBI, UNII | |
| biolink:MolecularMixture | CHEBI | |
| biolink:ComplexMolecularMixture | CHEBI | |
| biolink:Disease | MONDO | |
| biolink:PhenotypicFeature | HP |
Provenance Information¶
Contributors: - Gwenlyn Glusman - code author, domain expertise, data modeling - Matthew Brush - data modeling - Sierra Moxon - code, data modeling