Multiomics Drug Approvals Knowledge Provider (DAKP) Reference Ingest Guide¶
Source Information¶
InfoRes ID: infores:multiomics-drugapprovals
Description: The Drug Approvals KP provides information on FDA-approved drugs and their approved indications, derived from DailyMed and FAERS data. Information includes drug-disease treatment relationships with FDA approval status, approval numbers, and supporting evidence from adverse event reports.
Citations: - Generating Biomedical Knowledge Graphs from Knowledge Bases, Registries, and Multiomic Data (preprint): (https://pmc.ncbi.nlm.nih.gov/articles/PMC11601480/
Data Access Locations: - Direct download links for the latest version are given in the manifest file: https://github.com/multiomicsKP/drug_approvals_kp/blob/main/manifest.json
Data Provision Mechanisms: file_download
Data Formats: kgx
Data Versioning and Releases: New versions are released periodically
Ingest Information¶
Ingest Categories: translator_knowledge_creator
Utility: DAKP provides curated drug-disease treatment relationships with FDA approval status and supporting evidence. This knowledge is essential for understanding approved therapeutic uses and clinical evidence.
Scope: FDA-approved drugs and their treatment relationships with diseases, including approval status, FDA approval numbers, and case counts from adverse event reporting.
Relevant Files¶
| File Name | Location | Description |
|---|---|---|
| DAKP processed data | https://db.systemsbiology.net/gestalt/KG/ | Drug approval data processed from DailyMed and FAERS |
Included Content¶
| File Name | Included Records | Fields Used |
|---|---|---|
| DAKP processed data | Drug-disease treatment relationships with FDA approval information | drug identifiers, disease identifiers, FDA approval numbers, approval status, case counts, evidence IDs |
Target Information¶
Target InfoRes ID: infores:translator-dakp-kgx
Edge Types¶
| Subject Categories | Predicate | Object Categories | Knowledge Level | Agent Type | UI Explanation |
|---|---|---|---|---|---|
| biolink:ChemicalEntity, biolink:SmallMolecule, biolink:MolecularMixture, biolink:ComplexMolecularMixture | biolink:Disease, biolink:PhenotypicFeature, biolink:DiseaseOrPhenotypicFeature | knowledge_assertion | text_mining_agent | The 'treats' predicate indicates an FDA-approved therapeutic relationship between a drug and a disease, with supporting regulatory approval information. |
Node Types¶
| Node Category | Source Identifier Types | Additional Notes |
|---|---|---|
| biolink:ChemicalEntity | CHEBI, UNII | |
| biolink:SmallMolecule | CHEBI, UNII | |
| biolink:MolecularMixture | CHEBI | |
| biolink:ComplexMolecularMixture | CHEBI | |
| biolink:Disease | MONDO | |
| biolink:PhenotypicFeature | HP |
Provenance Information¶
Contributors: - Gwenlyn Glusman - code author, domain expertise, data modeling - Matthew Brush - data modeling - Sierra Moxon - code, data modeling