CURE ID¶
Source Information¶
InfoRes ID: infores:cureid
Description: CURE ID is a free platform developed by FDA and NIH to share novel uses of existing drugs - also known as drug repurposing/off-label use - and explore what others have tried. The goal is to find potential treatments for challenging diseases that lack good treatment options. Our mission is to use the information collected from users sharing their treatment experiences publicly on CURE ID to help inform what drugs are studied in clinical trials. The findings from these trials will enable the medical community to learn whether a drug is effective or not for it’s new use.
Citations: - Farid T, Ruzhnikov MRZ, Duggal M, Tumas KC, Strongin S, Sid E, Fuchs SR, Sacks L, Pichard DC, Pilgrim-Grayson C, Mathé EA, Stone HA. CURE ID: A Platform to Collect Real-World Treatment Data for Drug Repurposing in Rare Genetic Disorders. Am J Med Genet C Semin Med Genet. 2025 Sep;199(3):189-193. doi: 10.1002/ajmg.c.32153. Epub 2026 Jan 7. PMID: 41496707
Data Access Locations: - https://opendata.ncats.nih.gov/public/cureid/ - https://cure.ncats.io/
Data Provision Mechanisms: file_download
Data Formats: tsv
Ingest Information¶
Ingest Categories: primary_knowledge_provider
Utility: CURE ID is a user documented source of real world evidence on drug repurposing opportunities for rare and difficult to treat diseases. It provides chemical-disease associations, adverse events, and treatment outcomes, among other information. Information is collected from case reports and series published in the medical literature.
Scope: This initial ingest focuses on case report entities and relationships for RASopathies as documented in CURE ID.
Relevant Files¶
| File Name | Location | Description |
|---|---|---|
| cureid_data.tsv | https://opendata.ncats.nih.gov/public/cureid/ | Manually and LLM curated associations between chemicals, diseases, phenotypic features, genes, and variants from case reports in Cure ID and series published in the medical literature. |
Included Content¶
| File Name | Included Records | Fields Used |
|---|---|---|
| cureid_data.tsv | All records | subject_type, subject_final_curie, subject_final_label, object_type, object_final_curie, object_final_label, association_category, biolink_predicate, outcome, pmid, link |
Target Information¶
Target InfoRes ID: infores:cureid
Edge Types¶
| Subject Categories | Predicate | Object Categories | Knowledge Level | Agent Type | UI Explanation |
|---|---|---|---|---|---|
| biolink:ChemicalEntity, biolink:SmallMolecule | biolink:Disease, biolink:PhenotypicFeature | knowledge_assertion | manual_agent | A CURE ID user (a patient or health care provider) has reported that a medication was applied_to_treat a particular disease or phenotype. | |
| biolink:SmallMolecule | biolink:Disease, biolink:PhenotypicFeature | observation | manual_agent | A CURE ID user (a patient or health care provider) has reported that a medication had an adverse event related to a particular disease or phenotype. | |
| biolink:Disease | biolink:Disease, biolink:PhenotypicFeature | knowledge_assertion | manual_agent | A CURE ID user (a patient or health care provider) has reported that a disease has a particular phenotype. | |
| biolink:Gene | biolink:Disease | knowledge_assertion | manual_agent | A CURE ID user (a patient or health care provider) has reported that a gene is associated with a particular disease. |
Node Types¶
| Node Category | Source Identifier Types | Additional Notes |
|---|---|---|
| CHEBI | ||
| MONDO, UMLS | ||
| HP, NCIT, UMLS | ||
| NCBIGene | ||
| UNII |
Provenance Information¶
Contributors: - Keith Kelleher - ingest code author - Jessica Maine - data cleansing, domain expertise - Tahsin Farid - domain expertise - Keyla Tumas - domain expertise