name: CURE ID
source_info:
  infores_id: infores:cureid
  description: "CURE ID is a free platform developed by FDA and NIH to share novel uses of existing drugs - also known as drug repurposing/off-label use - and explore what others have tried. The goal is to find potential treatments for challenging diseases that lack good treatment options. Our mission is to use the information collected from users sharing their treatment experiences publicly on CURE ID to help inform what drugs are studied in clinical trials. The findings from these trials will enable the medical community to learn whether a drug is effective or not for it’s new use."
  citations:
    - "Farid T, Ruzhnikov MRZ, Duggal M, Tumas KC, Strongin S, Sid E, Fuchs SR, Sacks L, Pichard DC, Pilgrim-Grayson C, Mathé EA, Stone HA. CURE ID: A Platform to Collect Real-World Treatment Data for Drug Repurposing in Rare Genetic Disorders. Am J Med Genet C Semin Med Genet. 2025 Sep;199(3):189-193. doi: 10.1002/ajmg.c.32153. Epub 2026 Jan 7. PMID: [ 41496707 ](https://pubmed.ncbi.nlm.nih.gov/41496707/)"
  data_access_locations:
    - https://opendata.ncats.nih.gov/public/cureid/
    - https://cure.ncats.io/
  data_provision_mechanisms:
    - file_download
  data_formats:
    - tsv

ingest_info:
  ingest_categories:
    - primary_knowledge_provider
  utility: >-
    CURE ID is a user documented source of real world evidence on drug repurposing
    opportunities for rare and difficult to treat diseases. It provides chemical-disease
    associations, adverse events, and treatment outcomes, among other information. Information is collected from 
    case reports and series published in the medical literature.
  scope: >-
    This initial ingest focuses on case report entities and relationships for RASopathies as documented in CURE ID.

  relevant_files:
    - file_name: cureid_data.tsv
      location: https://opendata.ncats.nih.gov/public/cureid/
      description: Manually and LLM curated associations between chemicals, diseases, phenotypic features, genes, and variants
        from case reports in Cure ID and series published in the medical literature.

  included_content:
    - file_name: cureid_data.tsv
      included_records: All records
      fields_used:
      - subject_type
      - subject_final_curie
      - subject_final_label
      - object_type
      - object_final_curie
      - object_final_label
      - association_category
      - biolink_predicate
      - outcome
      - pmid
      - link

target_info:
  infores_id: infores:cureid
  edge_type_info:
    - subject_categories:
        - biolink:ChemicalEntity
        - biolink:SmallMolecule
      predicates:
        - biolink:applied_to_treat
      object_categories:
        - biolink:Disease
        - biolink:PhenotypicFeature
      knowledge_level:
        - knowledge_assertion
      agent_type:
        - manual_agent
      edge_properties:
        - publications
      ui_explanation: A CURE ID user (a patient or health care provider) has reported that a medication was applied_to_treat a particular disease or phenotype.
    - subject_categories:
        - biolink:SmallMolecule
      predicates:
        - biolink:has_adverse_event
      object_categories:
        - biolink:Disease
        - biolink:PhenotypicFeature
      knowledge_level:
        - observation
      agent_type:
        - manual_agent
      edge_properties:
        - FDA_adverse_event_level
        - publications
      ui_explanation: A CURE ID user (a patient or health care provider) has reported that a medication had an adverse event related to a particular disease or phenotype.
    - subject_categories:
        - biolink:Disease
      predicates:
        - biolink:has_phenotype
      object_categories:
        - biolink:Disease
        - biolink:PhenotypicFeature
      knowledge_level:
        - knowledge_assertion
      agent_type:
        - manual_agent
      edge_properties:
        - publications
      ui_explanation: A CURE ID user (a patient or health care provider) has reported that a disease has a particular phenotype.
    - subject_categories:
        - biolink:Gene
      predicates:
        - biolink:associated_with
      object_categories:
        - biolink:Disease
      knowledge_level:
        - knowledge_assertion
      agent_type:
        - manual_agent
      edge_properties:
        - publications
      ui_explanation: A CURE ID user (a patient or health care provider) has reported that a gene is associated with a particular disease.
  node_type_info:
    - node_categories:
        - biolink:SmallMolecule
      source_identifier_types:
        - CHEBI
    - node_categories:
        - biolink:Disease
      source_identifier_types:
        - MONDO
        - UMLS
    - node_categories:
        - biolink:PhenotypicFeature
      source_identifier_types:
        - HP
        - NCIT
        - UMLS
    - node_categories:
        - biolink:Gene
      source_identifier_types:
        - NCBIGene
    - node_categories:
        - biolink:ChemicalEntity
      source_identifier_types:
        - UNII

provenance_info:
  contributions:
    - "Keith Kelleher - ingest code author"
    - "Jessica Maine - data cleansing, domain expertise"
    - "Tahsin Farid - domain expertise"
    - "Keyla Tumas - domain expertise"